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Dihexa significantly decreased levels of pro-inflammatory cytokines including interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), both implicated in synaptic dysfunction and neuronal death in Alzheimer's disease

Researchers have also reported no significant negative effects on standard organ-function markers in short-term dosing

The authors noted that the compound lacks FDA approval and that the published record remains overwhelmingly preclinical

Every peptide bond is theoretically susceptible to hydrolysis, but some are more vulnerable than others

the evidence base is four separate single-compound literatures