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Finally, we discuss the major translational challenges that currently limit the precision, selectivity, and clinical applicability of these systems, and outline future directions for the development of next-generation lysosome-centered nanotherapeutics

Glucocorticoid-induced osteoporosis Chronic steroid use devastates bone

HGH (recombinant GH) supplies exogenous GH directly (bypassing hypothalamic/pituitary control), producing higher circulating GH levels but without restoring physiological pulsatility

Expect initial rapid weight loss of 2-4 pounds per week, slowing to 1-2 pounds per week after the first month, then 0.5-1 pound per week as you approach maintenance

Both IM and SQ can achieve that goal