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The SUSTAIN cardiovascular outcome trial programme demonstrating significant reduction in major adverse cardiovascular events in type 2 diabetes patients, and the SELECT trial demonstrating cardiovascular event reduction in obese patients without diabetes, have further established Semaglutide as a cardioprotective agent with GLP-1R-mediated cardiovascular biology extending beyond glycaemic and weight management

Regular monitoring of HbA1c (individualised targets, typically 4853 mmol/mol depending on therapy and hypoglycaemia risk), body weight, and thyroid function allows timely treatment adjustments and helps identify when additional interventions are needed

These effects, observed in animal models, have been linked to improvements in muscle physiology and cardiac performance

Since the FDA didnt approve compounded semaglutide, there are still questions about its effectiveness