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As expected, refeeding induced a rapid decline in ghrelin to similar levels in female and male WT and Tmprss2 / mice (Figure 2K)
In the systemic circulation, endothelial dysfunction, detectable in healthy individuals with normal brachial blood pressure, is associated with increased central pulse pressure and systemic arterial stiffening
One of the main identified targets is the nitric oxide (NO) pathway, where the peptide acts as a modulator of NO synthesis via NO synthase (NOS) enzymes
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