Tirzepatide produces greater weight loss and may have stronger effects on insulin sensitivity
While more studies in psychiatric populations are needed, obesity and antipsychotic-induced obesity are more alike than different, and it is likely that other GLP-1 RAs will work in this population as well
The prognosis is poor, with a 5-year survival rate generally in the range of 10-25%
Compounds targeting ferroptosissuch as iron chelators, lipid peroxidation inhibitors, antioxidants, and radical scavengersmay exert their neuroprotective effects by modulating iron metabolism, lipid oxidation, and redox homeostasis (114, 225235)
Its direct CNS-targeted mechanism sets it apart from peptides that influence peripheral pathways, making it particularly valuable for investigations centered on neurological and behavioral regulation