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Doubling up increases the risk of severe GI side effects without improving efficacy, and semaglutide's seven-day half-life means therapeutic levels persist even with one missed dose

Additionally, age can lead to slower motility, the movement of food and waste through the digestive tract

Inconsistent use will greatly reduce its effectiveness

75% of patients who initiate a diabetes-indicated GLP-1 have filled metformin or another diabetes treatment prior to initiation, while the majority of weight-loss indicated GLP-1 initiators have had no prior fills of any diabetes products

However, glucagon levels remain high in fasting and postprandial states