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while 7 of the 12 patients reported subjective pain relief exceeding six months, the complete absence of a placebo control group or standardized pain-scale methodology severely limits the scientific validity and reproducibility of the findings

Sign of toxicity include diarrhoea and generalised body oedema Dosage: The most common dosage is 1000mcg which is 1 ml per treatment every 4-6 weeks This can be given via IM injection in the arm or the bum

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[12] Parenteral choline supports fetal neurodevelopment, yet the safety of supraphysiologic methyl-donor combinations in pregnancy lacks robust evidence

Management: Rotate injection sites regularly