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The cycle structure exists for a practical reason: continuous stimulation of the same receptor pathways can lead to reduced sensitivity over time, and a rest period allows the system to reset before the next cycle produces full effect
You may also qualify if your BMI is over 27 and you have a weight-related health condition, such as high blood pressure, diabetes, heart disease or raised cholesterol
doi: 10.1186/s13046-018-0975-0 35
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