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It: Stimulates insulin secretion (only when glucose is elevated) Suppresses glucagon Slows gastric emptying Reduces appetite Promotes satiety Due to these effects, GLP-1 plays a central role in blood glucose regulation, weight management, and metabolic health

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28 The challenge to develop an oral preparation for semaglutide ascribes by a hydrophilic, macromolecular peptide is naturally susceptible to low pH and gastric/intestinal enzymes, as well as poor gastrointestinal absorption

For retatrutide specifically, as it remains an investigational medicine, any adverse events experienced within a clinical trial setting should be reported directly to the trial sponsor and principal investigator in accordance with the trial protocol

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