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Serum B12 and basic hematologic tests usually provide a clear answer

Injection-site reactions are among the most commonly reported side effects: patients may experience pain, stinging, or mild burning at the IM injection site

Acceptable alternative options have only recently become available

Complementary approaches such as siRNA-mediated NNMT knockdown, shRNA-mediated knockdown, CRISPR-based perturbation, or comparison with a structurally distinct NNMT inhibitor can help determine whether an observed phenotype follows NNMT biology rather than an unrelated chemical or solvent-associated effect