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Due to accumulation of metabolic intermediates, impaired carnitine biosynthesis, reduced protein intake, and increased removal of carnitine through hemodialysis (HD), patients who undergo routine HD usually present with plasma carnitine insufficiency [54]

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It is because high GSSG in a cell makes it prone to damage

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Safety assessments included treatment-emergent adverse events, serious adverse events and changes in vital signs and laboratory assessments according to the protocol