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Biol Chem Hoppe Seyler (1991) 372:30511

In a systematic review of patients suffering from cholestatic liver disease, those treated with a combination of Ursodeoxycholic acid (UDCA) and 1,200 mg/day of SAMe achieved a significantly higher "total effective rate" regarding improved liver enzymes and reduced clinical symptoms (such as severe itching and fatigue) compared to those receiving UDCA monotherapy

Gaithersburg, MD: Aspen Publishers, Inc., 1996 Found it

It is interesting to speculate as to whether progesterone-only contraceptives could indirectly alter insulin sensitivity (64, 65)

Presented for research literature review only Vacha GM et al