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doi:10.5812/ijem.101776
ORCID: Affiliation: 3 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA These authors contributed equally to this work
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In contrast, there are studies revealing that the activation of HIF1 signaling is not principally regulated by mutant IDH1, but more likely via other recognized mechanisms like hypoxia, transcriptional regulation, and major genetic and epigenetic alterations induced by gain-of-function or loss-of-function mutations 30
All authors contributed to thearticle and approved the submitted version
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