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Tesamorelin is a GHRH analogue designed to stimulate pituitary GHRH receptors to increase endogenous growth hormone (GH) and insulin-like growth factor-1 (IGF-1) secretion
This route completely bypasses first-pass metabolism in the liver, a major advantage over drugs that are swallowed and processed through the hepatic portal system
Some argue that prolonged activation of pancreatic GLP-1 receptors could lead to an overgrowth of cells in the organ
Metformin is not associated with pancreatitis risk
Cheng, C.-H., Chan, P.-Y
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