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They followed 173 RA patients with overweight or obesity who were prescribed and actually took a GLP-1 medication (semaglutide or tirzepatide) between 2018 and 2024, and compared them to 42 patients who were prescribed one but never took it
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One of the enzymes in this pathway, -butyrobetaine hydroxylase, is absent from cardiac and skeletal muscle but highly expressed in human liver, testes, and kidney [4]
While DKA is rare with GLP-1 receptor agonists, cases have been reported, particularly when concomitant insulin is rapidly reduced or discontinued
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