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Nature 493 , 689693 (2013)

LOX enzyme catalyzes the oxidative deamination of telopeptide lysine/hydrolysine residues to yield highly reactive aldehydes that further react to form immature and then mature permanent cross-links 16,17

Despite its growing popularity in biohacking circles and advanced longevity practitioners, Epitalons long-term safety remains unclear: No large-scale toxicology or pharmacokinetic studies in humans have been published

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A recent review further conclude that MAMs undergo morphological and functional alterations during aging and senescence (236)