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GLP-1, as an agonist, binds to the GLP-1 receptor and works to lower blood glucose by stimulating insulin secretion and to inhibit glucagon release
In the management of obesity, certain molecules have specific indications: for example, Wegovy (semaglutide) is indicated as an aid to weight management in combination with a low-calorie diet and increased physical activity
Several peptides, such as BPC-157 and TB-500, are banned by international sports authorities as doping substances
PubMed Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight Supports head-to-head context when pages compare older and newer GLP-1 options
Most clinicians prefer to start metformin first and titrate it to 1000 to 2000 mg daily over 2 to 4 weeks before adding semaglutide
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