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J.de BruijnE
SURMOUNT-1 (72-week randomized study, adults without diabetes): tirzepatide produced an average loss of 15.0% (5 mg dose), 19.5% (10 mg dose), and 20.9% (15 mg dose) of body weight, versus 3.1% with placebo, under a similar lifestyle-intervention protocol
95% CI 3.2 to 2.1
Compounds such as alpha-chloroacetamide-based inhibitors achieve this by covalently binding to a cysteine residue in the SAM-binding pocket of NNMT 202
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