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Taken together, these findings highlight that metabolic reprogramming not only provides energy and biosynthetic precursors for metastasis but also enables cancer cells to acquire invasive and migratory phenotypes
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demonstrated that in patients with breast cancer brain metastasis (BCBM), higher ferroptosis scores were associated with increased sensitivity to a wide range of chemotherapy drugs, including cisplatin, dasatinib, etoposide, gefitinib, lapatinib, pazopanib, sunitinib, docetaxel, and vinorelbine ( In conclusion, future research should focus on uncovering additional ferroptosis-related regulators and identifying biomarkers that can be used for patient stratification in breast cancer
Trials of unpatentable molecules typically depend on philanthropic, academic, or government funding, and that pipeline has not yet materialised for BPC-157
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