What pricing and reimbursement risks (e.g., VBP, biosimilar entry) could impact revenue forecasts after 2026
Although these data appear to conflict with our observation that tirzepatide stimulates alpha cell activity, it is important to note that the metabolic profile of the subjects in the tirzepatide arm improved dramatically during the 28-week period, complicating interpretations
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No human clinical trials have been completed for KLOW as a formulation, and no component peptide has regulatory approval for medical or therapeutic use
Immunohistochemically, as noted above, SNUC may show some staining for NSE, but in our experience they have generally lacked staining for most other neuroendocrine markers, including synaptophysin and chromogranin