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It was first described in research as an exercise-mimetic a compound that activates some of the same cellular pathways triggered by physical activity, even in sedentary states
A 12-week randomized clinical trial cited across NIH/PMC-indexed research on GHK-Cu's regenerative actions found significant anti-aging benefits from a GHK-Cu facial cream applied twice daily, including reduced fine lines, coarse wrinkles and mottled pigmentation, increased skin density and thickness, and strongly stimulated keratinocyte proliferation
Subcutaneous injection provides near 100% bioavailability and systemic distribution, whereas topical application is limited by skin barrier penetration
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doi:10.1016/j.cvsm.2018.07.007 12
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