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Poor sleep increases cortisol, drives insulin resistance, increases hunger hormones (even partially overriding GLP-1 appetite suppression), and impairs recovery from exercise

Patients with a history of allergic reactions to similar compounds or excipients present in the preserved formulation should exercise caution

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Patients can minimize these risks by using soft toothbrushes and electric razors and avoiding activities with injury risks. A 2022 study published in the Annals of Internal Medicine found apixaban to be the safest blood thinner among direct oral anticoagulants (DOACs), with the lowest risk of gastrointestinal bleeding