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What specific tissues show the greatest response to ipamorelin in animal models? Bone (trabecular and cortical), skin (dermal collagen), tendon/ligament connective tissue, and skeletal muscle show the most consistent responses in published studies

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Peripherally administered liraglutide has direct access to a limited number of brain regions, primarily circumventricular organs and a few sites in the hypothalamus (8), and CNS GLP-1Rs are important for its body weightlowering (BW-lowering) effect (9)