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Study Design: 203 obese patients (BMI 3040 kg/m) Randomized to tesofensine 0.25 mg, 0.5 mg, 1.0 mg, or placebo All groups received dietary counseling (mild energy restriction) Primary endpoint: change in body weight at 24 weeks Registered as NCT00394667 Key Results: The 0.5 mg dose produced 10.6% placebo-subtracted weight loss roughly double what existing anti-obesity drugs (sibutramine, orlistat) achieved at the time

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10.1016/j.ijcard.2018.12.005 51 SukumaranV.TsuchimochiH.SonobeT.WaddinghamM

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