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Journal of Investigative Dermatology 115(6):962-968. [doi.org]
Beyond its cytotoxic effects, Paclitaxel has shown immune-modulatory properties, specifically reprogramming TAMs from a tumor-promoting M2 phenotype to an antitumor M1 phenotype through TLR4 (Toll-like receptor 4) signaling
When stratified by comparator groups, the pooled estimate was most favorable in monotherapy trials versus placebo (SMD 2.41, 95% CI 4.43 to 0.39), whereas the add-on designs versus the same background treatment (SMD 0.65, 95% CI 1.85 to 0.55), head-to-head comparisons versus another drug (SMD 0.19, 95% CI 0.84 to 0.45), and add-on designs versus placebo (SMD 0.65, 95% CI 1.35 to 0.06) showed more modest estimates and did not provide clear evidence of a between-group difference overall (p=0.21)
Does body weight affect AOD-9604 dosing
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