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Both above studies suggest that MTHFR polymorphisms might enhance the environmental risks (low folate intake, traumatic stress at childhood) for MDD via the interaction between genetic and environmental factors
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What about folate
While supplements can help fill the gaps and provide targeted support through advanced delivery, they work best when paired with a healthy lifestyle
Zhang JH, Hanesworth JM, Sardinia MF, Alt JA, Wright JW, Harding JW
NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor
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