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Cleveland Clinic explains that muscle tissue is metabolically active, meaning it requires energy to maintain itself. Harvard Health Publishing also notes that muscle burns more calories than fat and that total muscle mass is closely tied to resting metabolic rate

Tirzepatide: A novel cardiovascular protective agent in type 2 diabetes mellitus and obesity

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Despite the lack of rigorous clinical studies, case studies and independent experimental use have consistently yielded good results with few reports of adverse effects