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[Accessed on 11 June 2026] Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment (2025)

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Depicts MTHFR variant activity For example, an individual who is heterozygous at both C677T (C/T) and A1298C (A/C), known as a compound heterozygote, is expected to exhibit a 55% decrease in MTHFR enzymatic activity (35% activity due to the presence of one T allele at C677T and 20% activity due to the presence of one C allele at A1298C = 55%)