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No changes in IGF-1

These microbial-derived signals activate hepatic immune pathways, including toll-like receptor-mediated responses, thereby promoting inflammation, hepatocellular injury, and fibrogenesis

In conclusion, there is now substantial evidence that increased intestinal permeability is associated with immune activation and symptoms like pain and diarrhea in IBS

This underscores the importance of developing sustainable lifestyle habits during the treatment period, not relying solely on the medication for long-term results