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Participants were assigned in a two-to-one ratio to receive either oral semaglutide 25 milligrams once daily or placebo, alongside standardized lifestyle interventions that included diet and physical activity counseling
Any questions about personal risk level should be discussed with a healthcare provider before starting treatment
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Participants took a single oral dose of metoprolol, waited a one-week washout, then received subcutaneous retatrutide followed by a second oral dose of metoprolol
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