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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice

Such modulatory effects on cholesterol levels hint at its broader applicability, beyond just weight reduction, perhaps in the realm of metabolic health optimization [Usman et al., 2022]

This substrate site-targeting mechanism provides selectivity over related methyltransferases and other NAD salvage pathway enzymes in laboratory assay systems

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