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Dose-Response at 24 Weeks The 24-week data illustrate the dose-response relationship during the mid-treatment phase: Phase 3 Results: Extended Timeline Data TRIUMPH-4 (68 Weeks) The TRIUMPH-4 Phase 3 trial extended the treatment duration to 68 weeks in 445 adults with obesity and knee osteoarthritis

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Conclusion: In subjects with obesity and high ALT, semaglutide 0.2-0.4 mg daily reduced ALT to an extent that was broadly comparable across weight loss categories, and resulted in dose-related ALT normalization in up to 46% of subjects after 52 weeks