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In this study, both AOD9604 and HA individually led to improved cartilage outcomes and shorter periods of lameness compared to saline control
pre- and post-operative treatment, when requirements are increased as in fever, severe burns, increased metabolism, pregnancy, gastrointestinal disorders interfering with intake or absorption of vitamins, prolonged or wasting diseases, alcoholism and where other deficiencies exist
Magsaysay described the effect as a kind of deferring of pain, which Wersland agreed was a useful way to picture it
Maintenance phase (weeks 512): 22.5 mg SC, once weekly
Synergistic use can harness their strengths, though rigorous human trials are still needed
