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Based on current clinical trial data, tirzepatide (Zepbound/Mounjaro) at the 15 mg dose produces the highest average weight loss approximately 2022% of body weight, or around 48 lbs on average in the SURMOUNT-1 trial
Rhayem, C
This could be due to enhancement of hepatic amino-acid catabolism with hepatic glucagon receptor activation
Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgery
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