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demonstrated that GABA (1.5 gr/kg/day, IP) normalized hyperglycemia, improved insulin sensitivity (measured by insulin clamp), reduced liver glucagon receptor mRNA (but not glucagon levels), and increased muscle GLUT4 translocation to plasma membrane as well as GLUT4 mRNA expression ( i.p

And so, GLP-1 receptor agonists improve blood glucose control directly by promoting insulin secretion and indirectly by facilitating weight loss

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Its glucagon receptor activation , though historically associated with hyperglycemia, is balanced by GLP-1 and GIP action , creating a net glycemic improvement