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Pregnant people should not take semaglutide because semaglutide's safety during pregnancy is not well-established

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Some early data suggests Retatrutide may preserve muscle mass better than GLP-1-only drugs, possibly due to the glucagon receptors effects on protein turnover, but this needs confirmation in dedicated body composition studies

After two centuries of differing medical advice, most authorities today think diabetics can have the same dietary freedom as the rest of us if insulin therapy and other blood-sugar-lowering medications are used

In February 2025, the FDA announced that the nationwide shortage of semaglutide injections was resolved