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The needle question comes up a lot

Observed molecular and cellular responses are highly dependent on experimental conditions, concentration, exposure duration, and model system

JAMA , 303 (16), 1603

A typical tapering protocol reduces the dose by 25 to 50% every four weeks, mirroring the same step-down intervals used during dose escalation

The physical examination included: (i) ankle reflexes, which were scored as normal (0 point), present only with reinforcement (1 point), or totally absent (2 points)