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Because this study involved patients who required additional HbA 1c control, although semaglutide reduced HbA 1c , not all patients were able to reduce their other diabetes medications, which depended on the baseline HbA 1c level and the level upon completion of semaglutide titration
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[14] [15] Furthermore, extremely low caloric intake can trigger adaptive metabolic responses, including reduced basal metabolic rate and hormonal changes that may make subsequent weight management more challenging
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