Notably, while markers of type I collagen synthesis and degradation are frequently used to indicate changes in bone turnover, they may also reflect changes in liver fibrogenesis or fibrinolysis (324, 325)
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These include: Pain, redness, or swelling at the injection site Bruising or hardening of tissue (induration) Itching or warmth around the injection area Temporary discolouration of the skin These localised reactions typically resolve within 2472 hours