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These changes to normal gastrointestinal physiology explain why diarrhea (defined as three or more loose or watery stools per day) and other gastrointestinal symptomsincluding nausea, vomiting, constipation, and abdominal painare among the most frequently reported side effects
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AMG 133 results in full agonism of human GLP-1R (EC 50 = 24.4 pM) and activated cynomolgus monkey and mouse GLP-1R (EC 50 of 5.7 and 123 pM, respectively)
Supplementation with 300-600 mg/day has been shown to increase intracellular glutathione levels by 30-70% in cell culture and animal studies, with more modest increases in human trials (Suh et al., Proc Natl Acad Sci, 2004) [25]
State-by-State Snapshot for NPs: Key Takeaway for NPs : If youre in a full-practice state (or meet the experience threshold in states like IL or NY), you can prescribe GLP-1s and other weight-loss medications independentlyprovided youve documented the training/competence to do so
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