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Non-genetic predictors of BMI loss To analyse the dependence of achieved BMI loss on non-genetic factors such as drug type, dosage and time on treatment, we fit the following model: where drugType is an indicator variable that equals 1 for individuals using semaglutide and 0 for tirzepatide, dose represents the dose in milligrams, days treat represents the total days on the relevant drug and : represents an interaction term between two or more variables
Given their glucose-lowering effects, GLP-1s have become standard of care for type 2 diabetes, supplanting other medication classes such as sulfonylureas.2 In 2023, GLP-1s represented 63% of diabetes spend, up from 38% in 2020.2 While diabetes GLP-1s will continue to account for a greater portion of spend compared to obesity, costs related to GLP-1s prescribed for obesity are expected to grow at a faster rate over the next 3 years
Aziz Pirani and Dr
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However, robust clinical trial results and a surge in endorsements from celebrities and influencers have done more than simply elevated drugs like Ozempic and Wegovy into mainstream consciousness
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