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Rotate sites systematically with each injection, maintaining at least 12 inches spacing between sites to prevent tissue irritation
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There is evidence showing that GLP-1RAs can reduce the expression of cell apoptotic markers Bcl-2-associated x (Bax) and caspase-3 while upregulating Bcl-2 [99, 100], as well as protecting against lipotoxic stress via phosphoinositide 3-kinase (PI3K)/Akt/forkhead box proteins O1 (FoxO1) pathway [101]
10.1038/ncomms6020 107 ScheckhuberC
