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Animal models further demonstrate changes in adipose tissue signaling consistent with increased fatty acid mobilization and oxidation

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Although meta-analytical data on ketosis in non-T1DM populations are lacking, pharmacovigilance analyses from the FDA Adverse Event Reporting System (FAERS) have indicated a potential signal of ketosis risk in individuals without T1DM receiving GLP-1 RAs without concurrent SGLT2 inhibitors or insulin therapy 27

The gap helps identify any site-specific reactions