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In research contexts, subcutaneous GHK-Cu injection is being explored for its systemic effects particularly its potential to deliver anti-inflammatory, tissue-regenerative, and gene-expression-modulating effects to tissues beyond the skin, including muscles, joints, internal organs, and the central nervous system

The side effect profiles of these medications also connect to the expiration discussion

Similar effects have been demonstrated in rodent MSC, where treatment with Ex at 10ng/ml 2.4 nM led to upregulation of pancreatic genes such as PDX-1 , GLUT2 and Insulin as well as an increase in DTZ-positive cells [53, 54]

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Vermeire S, Chiorean M, Pans J et al (2021) Long-term safety and efficacy of etrasimod for ulcerative colitis: results from the open-label extension of the OASIS study