Supports transition from preclinical to clinical IBD research Favorable safety profile across all preclinical toxicology studies Effective in TNBS-colitis and cysteamine-duodenal ulcer models
When consumed orally, glutathione must survive the harsh acidic environment of the stomach, navigate intestinal absorption barriers, and undergo first-pass metabolism in the liver before reaching systemic circulation
Kopetz S , Morris VK, O'Neil B, Bridgewater JA, Graham J, Parkes EE, Saunders MP, Asken E, Goodwin L, Phillips C, Robertson J, Tilston C, Woodcock S, Cook N
The goal is to match the peptide to the right patient, the right injury, and the right recovery plan
A common RNA splicing signature is identified in patient fibroblasts carrying different FUS/TLS mutations, with many changes overlapping ones induced by reducing either FUS/TLS or SMN