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4 Conclusions and perspectives In this review, we reported evidence of the crosstalk between endothelial cells and both myeloid cells and innate lymphocytes in the TME and the pathways that until now were described to modulate such a crosstalk

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In the last 50 years, tremendous progress has been made in understanding the pathophysiology and pathobiological complexities of SCD, but developing treatments has been disproportionately slow and elusive