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Although the human relevance of these findings remains uncertain, as human C-cells have lower GLP-1 receptor expression compared to rodents, the potential risk necessitates avoiding this medication in patients with any personal or family history of medullary thyroid carcinoma
After three washes with TBST, membranes were incubated with horseradish peroxidase-conjugated secondary antibodies (Jackson Immunoresearch, Pennsylvania, USA) for 1.5 h at room temperature
10.1038/npp.2016.246 101
RAASis with the maximally recommended or maximally tolerated dose of ACEi or ARB are the standard of care for prevention and treatment of CKD in people with diabetes, and they provide benefit over and above the effect of controlling BP [13]
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