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Furthermore, TMAO increased aortic plaque area and altered bile acid composition in male ApoE (-/-) mice, accelerating aortic lesions by modifying bile acid profiles, activating FXR and small heterodimer partner, and inhibiting bile acid synthesis (136)

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This receptor specificity makes it a reference reagent for investigating clean GH-axis activation and downstream effects on body composition, bone density, and metabolic homeostasis