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In a randomized, controlled, double-blind trial, the addition of 200 mg CoQ10 daily in people taking statins and omega-3 fatty acids improved a range of cardiovascular risk factors

Care goals: clarify glucose, weight, tolerability, nutrition, and quality-of-life priorities

CagriSema vs Tirzepatide (REDEFINE 4): strong weight loss, but an important endpoint miss Novo Nordisk has announced headline results from the open-label phase 3 REDEFINE 4 trial comparing CagriSema (cagrilintide + semaglutide) vs tirzepatide 15 mg in obesity

12 These outcomes are consistent with a maintained postprandial metabolic effect but note the important confound: in these trials cagrilintide is almost always studied with semaglutide, so cleanly attributing the postprandial glucose benefit to cagrilintides gastric or glucagon effects specifically is not straightforward

Unlike temporary pain relievers, Botox provides long-lasting relief with treatments typically needed every 12 weeks