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IGF-1 LR3 research provides valuable data on growth factor signaling in contexts where extended receptor activation is experimentally desirable

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Structure-activity relationship (SAR) studies have demonstrated that [10]: His : Provides an imidazole ring that forms hydrogen bonds with MC4R transmembrane domain residues D-Phe : The aromatic ring engages a hydrophobic pocket in the MC4R

PMCID: PMC2567835